One out of 10 people will be diagnosed with melanoma over their lifetime. While this used to be a death sentence of only months, research has made great strides over the last decade, extending life and hope by years. Dr. Sapna Patel, assistant professor in the Department of Melanoma Medical Oncology at the University of Texas MD Anderson Cancer Center and member of the Uveal Melanoma Assembly, is focused on bringing personalized medicine to melanoma patients. Melanoma mutations are either actionable and can be treated with readily available medications through what are known as Basket Trials, or they require deep genome profiling and access to higher levels of treatment. In both cases, drug therapy is focused on keeping the patient’s immune system “awake.” Using cutting-edge research, Dr. Patel remains committed to improving melanoma survival rates and, hopefully, introducing the other “C”—cure—into the conversation.